Neuroscience Insights: Advances in Brain Studies (ISSN: 3071-0138)
Review Article Volume: 1 & Issue: 1
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Abstract
An ischemic stroke occurs when the blood supply to cerebral region is obstructed, resulting in severe neuroinflammation and neuronal damage. ischemic stroke is one of the leading causes of death and permanent disability worldwide. The receptors expressed on the surface of
immune cells play a critical role in pathogenesis and recovery during and after cerebral ischemia. Important receptors of the innate and adaptive immune system like Pattern Recognition receptors, T cell Receptors and others for various ligands released by damaged brain cells initiate neuroinflammation, orchestrate inflammatory cascades and channelize diverse molecular pathways, thereby influencing neuroprotection and post stroke recovery. This review highlights important roles of these immune receptors in cerebral ischemia, focusing on their involvement in recognizing molecular patterns associated with cellular damage, modulating neuroinflammation and influencing the equilibrium between
inflammatory tissue damage and recovery. Additionally, the review also focusses on various strategies by which these receptors can be targeted for the development of novel stroke therapeutics. Since there is a scarcity of treatments available in the market for stroke patients, understanding the multifaceted role of these receptors may help in developing novel and potential stroke therapeutics.
Keywords: Cerebral ischemia, Pattern Recognition Receptors, Neuroinflammation, Immune receptors, Stroke Therapeutics.
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