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Journal of Case Reports and Reviews in Medicine (ISSN: 3069-0749)
Open Access | DOI: 10.64978/JCRRM
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Management of Statin Intolerance and Combined Dyslipidemia with a Monacolin K-Free Nutraceutical Formulation (LopiGLIK® BIO): A Clinical Case Report

B. Trimarco*1

1University of Naples Federico II, Italy.

*Correspondence: trimarco@unina.it

Received : September 30, 2026 | Published : October 07, 2026

Citation: Trimarco B. Management of Statin Intolerance and Combined Dyslipidemia with a Monacolin K-Free Nutraceutical Formulation(LopiGLIK® BIO): A Clinical Case Report. J Case Rep Rev Med. 2026;2(4):1-2. doi: 10.64978/jcrrm.2026.10070134

Copyright: © 2026 The Author(s). Published by SCIVOLVE.

License: This article is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0) , which permits use, sharing, adaptation, distribution, and reproduction in any medium or format, provided appropriate credit is given to the original author(s) and the source, a link to the Creative Commons licence is provided, and any changes made are indicated.

Abstract

Statin intolerance represents a significant clinical challenge in cardiovascular disease prevention, often leading to therapy discontinuation and uncontrolled lipid levels. Monacolin K-free nutraceuticals provide an alternative therapeutic strategy for lipid and glucose management without statin-related side effects. We report the case of a 58-year-old male with moderate hypercholesterolemia, impaired fasting glucose, and a history of statin-associated muscle symptoms (SAMS). After discontinuing statin therapy due to severe myalgia and elevated creatine kinase levels, the patient was started on a daily oral formulation of LopiGLIK® BIO — a nutraceutical containing Trigonella foenum-graecum (fenugreek), Morus alba, and Niacin. After 12 weeks of treatment, the patient showed a signifi cant improvement in lipid levels, with a 22% reduction in low-density lipoprotein cholesterol (LDL-C) and a 19% reduction in total cholesterol, along with stabilized fasting plasma glucose, without experiencing any muscular or gastrointestinal adverse effects. This case highlights the clinical utility and safety of a monacolin K-free nutraceutical combination in managing cardiovascular risk in statin-intolerant patients.

keywords: Statin Intolerance; Dyslipidemia; LopiGLIK BIO; Nutraceuticals; Fenugreek; Morus alba; Monacolin K-free.

Introduction

Elevated low-density lipoprotein cholesterol (LDL-C) remains a primary modifiable risk factor for coronary artery disease and cardiovascular events.1 While HMG-CoA reductase inhibitors (statins) are the cornerstone of lipid-lowering therapy, statin- associated muscle symptoms (SAMS) aff ect a non-negligible proportion of patients, leading to non-adherence or treatment discontinuation.2

Furthermore, emerging evidence suggests that controlling both glycemia and lipid profiles simultaneously yields greater overall cardiovascular protection.3 Red yeast rice derivatives containing monacolin K have been widely used as natural alternatives; however, monacolin K shares the same chemical structure as lovastatin and can trigger similar adverse muscle reactions in sensitive individuals.

LopiGLIK® BIO is an innovative, monacolin K-free oral formulation (15 mL vials) combining Trigonella foenum-graecum (fenugreek), Morus alba (white mulberry), and Niacin. Trigonella foenum-graecum supports lipid metabolism, significantly lowering LDL-C and total cholesterol; Morus alba inhibits carbohydrate absorption and improves glucose homeostasis; and Niacin contributes to normal energy-yielding metabolism and cardiovascular risk reduction. We present a case of a statin- intolerant patient successfully treated with LopiGLIK® BIO.

Case Presentation

A 58-year-old male patient with a history of mild hypertension and moderate dyslipidemia presented to our outpatient clinic for cardiovascular risk management. His previous therapy included Atorvastatin 20 mg/day, which was discontinued four weeks prior due to severe bilateral thigh myalgia and persistent weakness. Laboratory testing at that time revealed elevated serum creatine kinase (CK) levels (380 U/L; normal range < 190 U/L).

Upon presentation, the physical examination was unremarkable (BMI: 27.4 kg/m2; Blood Pressure: 128/82 mmHg). Baseline laboratory evaluation showed:

  • Total Cholesterol: 245 mg/dL
  • LDL-C: 162 mg/dL
  • HDL-C: 44 mg/dL
  • Triglycerides: 195 mg/dL
  • Fasting Plasma Glucose (FPG): 108 mg/dL
  • HbA1c: 5.9%
  • Creatine Kinase (CK): Normalised (115 U/L)

Given the patient’s complete intolerance to statins and his preference for a natural, non-statin approach, lifestyle modification (Mediterranean diet and moderate exercise) was reinforced, and treatment with LopiGLIK® BIO (1 oral vial of 15 mL once daily) was initiated.

Results / Follow-up

The patient tolerated the therapy exceptionally well, reporting full adherence and no recurrent muscular symptoms or gastrointestinal discomfort.

At the 12-week follow-up, laboratory reassessment showed signifi cant metabolic improvements:

  • Total Cholesterol: 198 mg/dL (19.2% reduction)
  • LDL-C: 126 mg/dL (22.2% reduction)
  • Triglycerides: 160 mg/dL (17.9% reduction)
  • HDL-C: 46 mg/dL
  • Fasting Plasma Glucose: 96 mg/dL

Table 1:

Parameter Baseline Week 12 Change (%)
Total Cholesterol (mg/dL) 245 198 -19.2%
LDL-C (mg/dL) 162 126 -22.2%
Triglycerides (mg/dL) 195 160 -17.9%
Fasting Glucose (mg/dL) 108 96 -11.1%

Discussion

Managing cardiovascular risk in patients with statin intolerance requires effective, well-tolerated alternatives. Monacolin K, although natural, poses risks similar to statins in individuals prone to SAMS. Therefore, monacolin K-free formulations represent a safer lipid-lowering option.

In this case, LopiGLIK® BIO demonstrated clinical efficacy comparable to preliminary clinical evaluations (which show approximately a 20% reduction in total cholesterol and 25% in LDL-C).

The synergistic action of its active components contributed to this comprehensive response:

  1. Trigonella foenum-graecum: Systematic review and meta-analysis data confirm its significant lipid-lowering effect on total cholesterol, LDL-C, and triglycerides.5
  2. Morus alba: Contributes to carbohydrate metabolism regulation by reducing postprandial glucose spikes and improving insulin sensitivity.6
  3. Niacin: Enhances lipid profiles and energy metabolism, aligning with observational studies showing cardiovascular benefit from niacin intake.4

The liquid formulation (single 15 mL vial per day) also facilitated excellent patient compliance and satisfaction.

Conclusion

LopiGLIK® BIO offers a safe, effective, and well-tolerated option for lipid and glycemic management in subjects with statin intolerance or muscle sensitivity. The combination of Trigonella foenum-graecum, Morus alba, and Niacin addresses both lipid and carbohydrate metabolic pathways without triggering statin-like muscular adverse effects. Long-term clinical trials are encouraged to confirm these findings in broader populations.

References

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