Journal of Case Reports and Reviews in Medicine (ISSN: 3069-0749)

Safety of Hyaluronic Acid and Botulinum Toxin Aesthetic Treatment Among Breast Cancer Patients

Magda Palka-Kotlowska, Sara Custodio-Cabello, Vilma Pacheco-Barcia, Eduardo Oliveros Acebes, Beatriz Chacón-Ovejero, Emilce Insua-Nipoti, Luis Cabezon-Gutierrez

Received : September 07, 2025 | Published : November 03, 2025

Citation: Palka-Kotlowska M, Custodio-Cabello S, Pacheco-Barcia V, et al. Safety of Hyaluronic Acid and Botulinum Toxin Aesthetic Treatment Among Breast Cancer Patients. J Case Rep Rev Med. 2025;1(4):1-5. DOI: 10.64978/jcrrm-0114

Abstract

Background: Aesthetic and functional consequences of cancer treatments often affect the quality of life and self-image of breast cancer survivors. Increasingly, patients seek nonsurgical aesthetic procedures such as hyaluronic acid (HA) fillers and botulinum toxin type A (BTX-A) treatments. However, evidence regarding the safety of these procedures in this population is limited.

Methods: We conducted a systematic literature review to evaluate the safety and efficacy of facial aesthetic treatments using HA fillers and BTX-A in breast cancer patients. Articles involving oncologic populations and aesthetic procedures were identified through major medical databases.

Results: The search revealed scarce data on facial aesthetic treatments in breast cancer survivors. Only one post-marketing study addressed aesthetic treatments in this population, reporting favorable safety outcomes in nine breast cancer patients undergoing HA filler and BTX-A treatment after completing chemotherapy. Additional literature focused on other oncological applications of BTX-A, such as pain and spasticity management, confirming its safety profile. Although HA has been used in reconstructive and supportive oncology care, few complications were noted when administered outside periods of active oncologic treatment.

Conclusion: The use of BTX-A and HA for facial aesthetic purposes appears safe in breast cancer patients who have completed chemotherapy and radiotherapy at least six months prior, provided their general health is stable. There is insufficient evidence to recommend these treatments during ongoing systemic therapies. As survivorship care increasingly prioritizes body image and quality of life, further research is warranted to establish evidence-based guidelines in onco-aesthetic medicine.