Journal of Case Reports and Reviews in Medicine (ISSN: 3069-0749)

Atypical Presentation of Extraskeletal Ewing Sarcoma During Pregnancy: A Case of Rapid Progression and Unusual Metastasis

Dr. Rafia Shahzad, Dr. Maryam Ikram, Dr. Zeeshan Rashid Mirza, Dr. Amira Shami

Received : September 11, 2025 | Published : October 09, 2025

Citation: Shahzad R, Ikram M, Mirza ZR, Shami A. Atypical Presentation of Extraskeletal Ewing Sarcoma During Pregnancy: A Case of Rapid Progression and Unusual Metastasis. J Case Rep Rev Med. 2025;1(4):1-3. DOI: 10.64978/jcrrm-0104

Abstract

Background: Extraskeletal Ewing sarcoma (EES) is a rare soft-tissue tumor with aggressive behavior and poor prognosis, especially when metastasized. Primary cutaneous manifestations are extremely uncommon.

Case Presentation: We report a case of a 22-year-old pregnant woman presenting with infraumbilical subcutaneous nodules that rapidly progressed postpartum. Histopathology confirmed EES. Imaging revealed widespread metastasis to the breasts, lungs, liver, bones, and brain. Due to systemic involvement, palliative chemotherapy and radiotherapy were initiated but patient could not bear the disease and treatment burden and unfortunately died after 6 months.

Conclusion: This case highlights an aggressive presentation of EES with rare metastatic spread, underscoring the need for early suspicion and the role of imaging in guiding management.

Keywords: Extraskeletal Ewing Sarcoma; Breast Metastasis; Brain Metastasis; Cutaneous Manifestations; Chemotherapy